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- Title
Normochromic normocytic anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormone.
- Authors
Anastasilakis, Athanasios D; Savvides, Mattheos; Polyzos, Stergios A; Georgopoulos, Christos; Delaroudis, Sideris
- Abstract
Intermittent exogenous parathyroid hormone (PTH) is a potent osteoanabolic agent used for the treatment of severe osteoporosis. Two molecules of recombinant PTH are commercially available: the full-length PTH (PTH 1-84) and teriparatide (PTH 1-34). We present the first report of PTH-induced mild, asymptomatic, normochromic normocytic anemia in a postmenopausal woman treated sequentially with PTH 1-84 and PTH 1-34. Anemia was more pronounced with PTH 1-84 compared to PTH 1-34 and was reversed with each regimen discontinuation. We suggest monitoring of hematocrit and hemoglobin in PTH-treated patients, especially when PTH 1-84 is used.
- Subjects
RECOMBINANT proteins; ANEMIA; DIPHOSPHONATES; DRUG monitoring; OSTEOPOROSIS; PARATHYROID hormone; DISEASE complications; TERIPARATIDE; THERAPEUTICS
- Publication
Journal of Bone & Mineral Metabolism, 2010, Vol 28, Issue 1, p108
- ISSN
0914-8779
- Publication type
journal article
- DOI
10.1007/s00774-009-0105-3