We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impairment of Vascular Homeostasis in Acute Heart Failure: Enter the Monocyte?
- Authors
Liu, Saifei; Lawrie, Indy AJ; Rabia, Bibi; Horowitz, John D.
- Abstract
This article discusses the impairment of vascular homeostasis in acute heart failure and the potential role of monocytes in this process. It highlights the importance of the endothelial glycocalyx (eGC), a mesh of glycoproteins and proteoglycans on the surface of vascular endothelial cells, in maintaining vascular function and permeability. Damage to the eGC is associated with increases in microvascular resistance and leakage, which can contribute to the development of acute pulmonary edema and inflammation. The article also explores the relationship between eGC damage and monocyte activation, suggesting that monocyte activation and shedding of the monocyte glycocalyx (mGC) may further exacerbate inflammation in acute heart failure. The findings of this study have implications for potential therapeutic strategies aimed at stabilizing the eGC and mGC to mitigate the pathophysiological consequences of acute heart failure.
- Subjects
HEART failure; MYOCARDIAL infarction; FUROSEMIDE; HOMEOSTASIS; VASCULAR endothelial cells; VENOUS pressure
- Publication
Cardiovascular Drugs & Therapy, 2024, Vol 38, Issue 3, p405
- ISSN
0920-3206
- Publication type
Abstract
- DOI
10.1007/s10557-024-07560-6