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- Title
Senescence and associated blood–brain barrier alterations in vitro.
- Authors
Salvador, Ellaine; Burek, Malgorzata; Löhr, Mario; Nagai, Michiaki; Hagemann, Carsten; Förster, Carola Y.
- Abstract
Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood–brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within.
- Subjects
AGING; BLOOD-brain barrier; CENTRAL nervous system; CELL junctions; ENDOTHELIAL cells
- Publication
Histochemistry & Cell Biology, 2021, Vol 156, Issue 3, p283
- ISSN
0948-6143
- Publication type
Article
- DOI
10.1007/s00418-021-01992-z