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- Title
Serum Beta-2-Microglobulin Levels in Intrauterine Growth-Restricted and Normal Pregnancies.
- Authors
Kontara, Louiza; Briana, Despina D.; Baka, Stavroula; Boutsikou, Maria; Marmarinos, Antonios; Gourgiotis, Dimitrios; Malamitsi-Puchner, Ariadne
- Abstract
Objective: It was the aim of this study to investigate circulating levels of β2-microglobulin (a marker of renal function) in mothers and fetuses/neonates from intrauterine growth-restricted (IUGR, characterized by impaired nephrogenesis) and appropriate for gestational age (AGA) pregnancies. Methods: Serum β2-microglobulin levels were determined in 40 parturients and their 20 IUGR and 20 AGA fetuses/neonates on postnatal days 1 (N1) and 4 (N4). Comparatively, creatinine concentrations were measured. Results: No significant differences in β2-microglobulin levels were observed between the 2 groups. In both groups, maternal serum β2-microglobulin levels were significantly lower than fetal, N1 and N4 levels (in all casesp < 0.001 in the AGA group and p ≤ 0.002 in the IUGR group). In the AGA and IUGR groups, N4 β2-microglobulin levels were significantly elevated compared with fetal (p = 0.004 and p = 0.001, respectively) and N1 levels (p = 0.002 andp = 0.001, respectively). In both groups, maternal and fetal β2-microglobulin levels did not correlate, but β2-microglobulin and creatinine levels positively correlated in maternal and neonatal samples (in all cases r ≥ 0.342 and p ≤ 0.031). Conclusions: Serum β2-microglobulin levels do not differ between IUGR and AGA groups, significantly increase after birth and are not associated with gender or gestational age. Furthermore, maternal levels do not correlate with fetal levels, implying the presence of a placental barrier. Copyright © 2008 S. Karger AG, Basel
- Subjects
SERUM; FETUS; GESTATIONAL age; NEWBORN infants; MOTHERS
- Publication
Fetal Diagnosis & Therapy, 2008, Vol 24, Issue 3, p220
- ISSN
1015-3837
- Publication type
Article
- DOI
10.1159/000151342