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- Title
Experimental Leishmania major Infection Suppresses HIV-1 DNA Vaccine Induced Cellular Immune Response.
- Authors
Robinson, Tara M.; Nelson, Robin; Artis, David; Scott, Phillip; Boyer, Jean D.
- Abstract
The AIDS epidemic in the developing world represents a major global crisis and an effective vaccine is imperative. However, many parasites are common in developing countries and can result in a state of chronic immune activation that is polarized towards a Th2 profile and which can potentially impair responses to vaccines or other infectious challenges. In this study we demonstrate that experimental Leishmania major infection of BALB/c mice inhibits responses to a DNA-based HIV-1 gag vaccine. L. major infection in BALB/c results in a polarized Th2 immune response. In this study naïve BALB/c mice immunized with the HIV-1 gag DNA vaccine mounted a cellular immune response against the vaccine antigen, HIV-1 gag. CD8+ T lymphocytes were able to respond in vitro to HIV-1 gag stimulation and secrete interferon (IFN)-γ. However, L. major-infected, vaccinated BALB/c mice had a significantly reduced number of IFN-γ-producing CD8+ T cells following in vitro stimulation with gag antigen. These data suggest that parasitic infection, which results in a Th2 profile, reduces the efficacy of DNA vaccines that are designed to induce antiviral CD8+ T cell responses. Copyright © 2004 S. Karger AG, Basel
- Subjects
DNA vaccines; SEXUALLY transmitted disease vaccines; HIV; AMASTIGOTES; TH2 cells
- Publication
Cells Tissues Organs, 2004, Vol 177, Issue 3, p185
- ISSN
1422-6405
- Publication type
Article
- DOI
10.1159/000079992