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- Title
Effect of vaginal energy-based treatment on female stress urinary incontinence: a systematic review and meta-analysis of randomized controlled trials.
- Authors
Zhang, Chi; Chen, Yuanzhuo; Liu, Shengzhuo; Chen, Jiawei; Shen, Hong; Luo, Deyi
- Abstract
Purpose: To evaluate the efficacy and safety of vaginal energy-based therapies in treating female SUI. Methods: The PubMed, EMBASE, Web of Science, and Scopus databases were searched up to September 2022 to identify RCTs comparing energy-based therapies with placebo intervention in treating female SUI. The primary outcome was International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) score. Secondary outcomes included the 1-h pad test and cure rate. Results: A total of 577 patients from 6 studies were included in the meta-analysis. Energy-based therapies did not significantly improve the ICIQ-SF score at all visits (≤ 1 month: SMD, -0.39; 95% CI − 0.80 to 0.03; P = 0.07; 3 months: SMD, − 1.32; 95% CI − 4.07 to 1.43; P = 0.35; 6 months: SMD, − 0.39; 95% CI − 0.91 to 0.12; P = 0.14). The subgroup analysis showed that there was no significant improvement in ICIQ-SF score in the CO2 laser group compared to the placebo group at all visits (≤ 1 month: SMD, − 0.13; 95% CI − 0.59 to 0.34; P = 0.59; 3 months: SMD, − 1.50; 95% CI − 3.91 to 0.92; P = 0.22; 6 months: SMD, 0.13; 95% CI − 0.47 to 0.72; P = 0.67). Meta-analysis was not performed in Er: YAG laser and radiofrequency therapy due to insufficient trials. Conclusion: Based on the limited clinical evidence, our meta-analysis showed no prior efficacy of energy-based therapy over placebo intervention. However, the results of this meta-analysis should be taken with caution due to the limited amount of available evidence and the heterogeneity among the included studies. PROSPERO registration number: CRD42022360471.
- Subjects
RANDOMIZED controlled trials; URINARY stress incontinence; YAG lasers; KEGEL exercises; RADIO frequency therapy; LASER therapy; VAGINAL medication; FEMALES
- Publication
World Journal of Urology, 2023, Vol 41, Issue 2, p405
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-022-04247-1