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- Title
Changing prevalence of glomerular diseases in Korean adults: a review of 20 years of experience.
- Authors
Chang, Jae Hyun; Kim, Dong Ki; Kim, Hyun Wook; Park, Sun Young; Yoo, Tae-Hyun; Kim, Beom Seok; Kang, Shin-Wook; Choi, Kyu Hun; Han, Dae-Suk; Jeong, Heon Joo; Lee, Ho Yung
- Abstract
Background. The prevalence of glomerular diseases differs according to geographic area, race, age and indications for a renal biopsy. This study was conducted to evaluate the distribution and changing patterns of renal diseases during the past 20 years in a large patient population in Korea. Methods. Patients aged 16 years or older who underwent a renal biopsy at Severance Hospital in the Yonsei University Health System from 1987 to 2006 were enrolled. All medical records were reviewed retrospectively. Results. In total, 1818 patients (M:F = 1.02:1) were reviewed. Glomerulonephritis (GN) comprised 85.9% of the total biopsied cases. The most common primary GN was IgA nephropathy (IgAN) (28.3%), which was followed by minimal change disease (MCD) (15.5%), membranous nephropathy (MN) (12.3%), focal segmental glomerulosclerosis (FSGS) (5.6%) and membranoproliferative GN (MPGN) (4.0%). The most common secondary GN was lupus nephritis (8.7%). The most common idiopathic nephrotic syndrome was MCD (38.5%), which was followed by MN and IgAN. Among 128 (7.4%) patients who were HBsAg-positive, MN (30.5%) and MPGN (21.1%) were the most common GN. When the incidence rates between 1987–91 and 2002–06 were compared, IgAN increased from 25.6 to 34.5%, while MCD (from 23.2 to 7.0%) and MPGN (from 6.7 to 1.7%) decreased significantly (P Conclusions. IgAN was the most common primary GN, and MCD was the most common cause of nephrotic syndrome. In the 5-year quartile comparison, the relative frequency of IgAN increased, while the relative frequency of MCD and MPGN decreased significantly during the past 20 years.
- Subjects
KIDNEY glomerulus diseases; DISEASE prevalence; ADULTS; DEMOGRAPHIC characteristics; CLINICAL indications; RENAL biopsy; KOREANS; POPULATION health; DISEASES
- Publication
Nephrology Dialysis Transplantation, 2009, Vol 24, Issue 8, p2406
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp091