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- Title
Serum Levels of Tripartite Motif-containing Protein 72 (TRIM72) in Iraqi Rheumatoid Arthritis Patients and Its Relevance to the Disease Activity State.
- Authors
Ahmed, Maryam Qais; Razak Al-Sharifi, Zainab A.; Gorial, Faiq
- Abstract
Background & Objective: Uncontrolled active rheumatoid arthritis patients have a progressive disability, pain, swelling problems, and stiffness that often lead to systemic complications, early death, socioeconomic costs, and comorbidity. The objectives of this study were to measure the serum levels of Tripartite motifcontaining protein 72 in Iraqi patients with rheumatoid arthritis and healthy individuals, assessment of the efficiency of Tripartite motif-containing protein 72, determine their essential serum rates in association with disease activity, sociodemographic and clinical specifications of the diseases. Materials & Methods: In this case-control study, 117 Iraqi patients with rheumatoid arthritis were investigated according to the 2010 American College of Rheumatology / European League Against Rheumatism from December 2020 to March 2022. The patients were divided into two groups. Group 1 were the RA patients with active disease, Group 2 were the RA patients with inactive disease, and healthy subjects served as the control group. Results: Serum levels of Tripartite motif-containing protein 72 in the active RA groups (101.92±160.18 Pg/mL) were significantly higher as compared with the inactive RA group (64.58±54.34 Pg/mL) and the control group (41.06 ±32.48 Pg/mL) (P˂0.005). Tripartite motif-containing protein 72 could not discriminate between RA and the controls (since its AUC ≥0.689). Conclusion: There was a positive relationship between DAS-28ESR and Tripartite motif-containing protein 72 levels, which induces bone erosion. The serum Tripartite motif-containing protein 72 level showed a significant elevation in rheumatoid arthritis patients compared with healthy controls. Tripartite motifcontaining protein 72 had a poor discriminative ability between RA and the control group.
- Subjects
IRAQ; RHEUMATOID arthritis diagnosis; PROTEINS; PEARSON correlation (Statistics); STATISTICAL correlation; ACADEMIC medical centers; T-test (Statistics); RECEIVER operating characteristic curves; RHEUMATOID arthritis; VISUAL analog scale; SYMPTOMS; DESCRIPTIVE statistics; CASE-control method; ONE-way analysis of variance; SOCIODEMOGRAPHIC factors; DATA analysis software; EARLY diagnosis; BIOMARKERS; SENSITIVITY &; specificity (Statistics); EVALUATION
- Publication
Journal of Advances in Medical & Biomedical Research, 2023, Vol 31, Issue 149, p602
- ISSN
2676-6264
- Publication type
Article
- DOI
10.30699/jambs.31.149.602