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- Title
F-041 REAL-TIME DETECTION OF METASTASES IN LYMPH NODES DURING THORACIC SURGERY.
- Authors
Enyedi, Attila; Csongor, V.; Szabó, K.; Takács, I.; Sasi Szabó, L.; Végh, T.; Tóth, L.; Balog, J.; Takáts, Z.
- Abstract
Objectives: Detecting lymph nodes containing metastases during surgery could change both the surgical procedure and the outcome. Rapid evaporative ionization mass spectrometry (REIMS) is a recently developed technique for real-time, in situ tissue identification. The objectives of this study were to test the “iKnife” method for the analysis of thoracic lymph nodes.Methods: REIMS is an emerging technique for characterization of human tissue by mass spectrometric analysis of the aerosol released during electrosurgical dissection. The first step in this study was the building of a tissue specific histologically validated database containing non-cancerous lymph node data and different types of lung cancers. The second step incorporated the analysis of these database spectra using multivariate statistical methods, and the saving of the calculated classification “model”. In the last step, the saved classification model was used for real-time classification of lymph nodes removed during surgery.Results: Hundred and twenty-five patients were recruited in the study. Cancerous tissue was collected from 97 patients and healthy lymph node tissue was collected from 93 patients. The classification “model” consisted of 239 healthy and 249 cancerous tissue; the cross-validation of this “model” resulted in 97.85% specificity and 96.95% sensitivity. The “model” was tested on an additional 6 patients with metastases in at least one of the sampled lymph nodes. Our algorithm identified cancer metastases in 17 cases, out of the 20 sampled cancerous lymph nodes, and marked 1 case as “outlier”. No cancer was identified in the sampled 6 healthy lymph nodes.Conclusions: The results presented here indicate that REIMS method is suitable for the detection of cancer metastases in lymph nodes based on a database built from healthy lymph nodes and cancerous alveolar lung tissue spectra. The lymphoid gland identification with the iKnife technique may significantly enhance real-time intraoperative decision-making and may result in increased patient survival rate.Disclosure: No significant relationships.
- Publication
Interactive Cardiovascular & Thoracic Surgery, 2014, Vol 18, Issue suppl_1, pS11
- ISSN
1569-9293
- Publication type
Article
- DOI
10.1093/icvts/ivu167.41