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- Title
Brazilian Expert Consensus for NTRK Gene Fusion Testing in Solid Tumors.
- Authors
Petaccia de Macedo, Mariana; Toledo Nascimento, Ellen Caroline; Augusto Soares, Fernando; Costa Santini, Fernando; D'Almeida Costa, Felipe; Werneck da Cunha, Isabela; Ramella Munhoz, Rodrigo; De Marchi, Pedro; Carnier Jorge, Thiago William; Moreira Leite, Kátia Ramos
- Abstract
Oncogenic neurotrophic tropomyosin receptor kinase gene fusions occur in less than 1% of common cancers. These mutations have emerged as new biomarkers in cancer genomic profiling with the approval of selective drugs against tropomyosin receptor kinase fusion proteins. Nevertheless, the optimal pathways and diagnostic platforms for this biomarker's screening and genomic profiling have not been defined and remain a subject of debate. A panel of national experts in molecular cancer diagnosis and treatment was convened by videoconference and suggested topics to be addressed in the literature review. The authors proposed a testing algorithm for oncogenic neurotrophic tropomyosin receptor kinase gene fusion screening and diagnosis for the Brazilian health system. This review aims to discuss the latest literature evidence and international consensus on neurotrophic tropomyosin receptor kinase gene fusion diagnosis to devise clinical guidelines for testing this biomarker. We propose an algorithm in which testing for this biomarker should be requested to diagnose advanced metastatic tumors without known driver mutations. In this strategy, Immunohistochemistry should be used as a screening test followed by confirmatory nextgeneration sequencing in immunohistochemistry-positive cases.
- Subjects
TUMOR diagnosis; BIOMARKERS; HIGH throughput screening (Drug development); IMMUNOHISTOCHEMISTRY; INDIVIDUALIZED medicine; GENETIC testing; MONOCLONAL antibodies; NUCLEOTIDES
- Publication
Clinical Pathology, 2023, Vol 16, p1
- ISSN
2632-010X
- Publication type
Article
- DOI
10.1177/2632010X231197080