We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyaluronic Acid as a LYVE-1 Receptor Ligand in the Lymphatic System of Healthy Human Skin.
- Authors
Michurina, S. V.; Svechnikova, N. N.; Konenkov, V. I.; Ishchenko, I. Yu.; Arkhipov, S. A.; Arkhipova, V. V.
- Abstract
Immunohistochemical detection of the LYVE-1 marker in healthy human full-thickness skin (the epidermis and the dermis) was carried out. LYVE-1 expression was found in the endothelium of lymphatic capillaries located in the papillary dermis, in the endothelium of larger lymphatic vessels of the reticular dermis, and in fibroblasts, which indicates their joint participation in hyaluronan metabolism. LYVE-1+ staining detected for the first time in cells of the stratum basale, the stratum spinosum, and the stratum granulosum of healthy human epidermis indicates their participation in hyaluronan metabolism and allows us to consider the spaces between epidermis cells as prelimphatics.
- Subjects
HYALURONIC acid; LYMPHATICS; DERMIS; ENDOTHELIUM; HUMAN beings; SKIN; EPIDERMIS
- Publication
Bulletin of Experimental Biology & Medicine, 2024, Vol 176, Issue 5, p636
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-024-06083-2