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- Title
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis.
- Authors
Zhang, Shilan; Kapoor, Sabeeta; Tripathi, Chakrapani; Perez, Jorge Tovar; Mohan, Nivedhitha; Dashwood, Wan Mohaiza; Zhang, Ke; Rajendran, Praveen; Dashwood, Roderick
- Abstract
ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.
- Subjects
COLORECTAL cancer; DNA repair; COLON cancer; CELL death; APOPTOSIS; DNA damage
- Publication
NPJ Precision Oncology, 2023, Vol 7, Issue 1, p1
- ISSN
2397-768X
- Publication type
Article
- DOI
10.1038/s41698-023-00361-4