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- Title
Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Perifollicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome.
- Authors
Elsayed Nouh, Amal Abd Elaziz; Abd Elhameid, Azza Abd Elmageid; Elhady Elsayed, Asmaa Mohamad Abd; Mahdy, Entsar Roshdy
- Abstract
Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine problem in females with an incidence of (6 -10%). The purpose of this study was to make a comparison between the effect of clomiphene citrate versus letrozole on the endometrial receptivity and perifollicular vascularity among infertile patients having PCOS. Methods: This randomized comparative clinical study was conducted at infertility clinic of laparoscopy cytogenic unit, Obstetrics and Gynecology Department, Zagazig University, Egypt from June 2019 to June 2020. It included a total of 54 infertile women diagnosed as having PCOS, 27 women received Clomiphene Citrate 100 mg and 27 patients received letrozole 5mg for ovulation induction. Thickness and pattern of the endometrium, uterine and spiral artery Doppler indices were calculated for 3 subsequent cycles on HCG injection day. Either clomiphene citrate or Letrozole was administrated by mouth for 5 days from day 3 of menstrual cycle. Results: As regards peri follicular vascularity, highly valuable difference was detected between two tested groups on HCG injection day in the 3 subsequent cycles. Ovulation rates were higher in the letrozole group than in the Clomiphene citrate group, however the discrepancy was not statistically valuable, in letrozole (70%, 74%, 81%) and in clomiphene citrate (63.0%, 67%, 77%) in 3 subsequent cycles. Conclusions: Both Clomiphene citrate and letrozole increase perifollicular blood flow with a significant difference in favor to letrozole, in letrozole group, the most of follicles were (grade3) and in Clomiphene citrate group (grade2).
- Subjects
EGYPT; LETROZOLE; POLYCYSTIC ovary syndrome treatment; CLOMIPHENE; LAPAROSCOPY
- Publication
Zagazig University Medical Journal, 2023, Vol 29, Issue 1, p28
- ISSN
1110-1431
- Publication type
Article
- DOI
10.21608/zumj.2021.59551.2117