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- Title
Diagnosis of Interstitial Lung Disease in Connective Tissue Disease Children: Retrospective Radiological Study.
- Authors
Domouky, Ayat M.; El-Beheidy, Rabab M.
- Abstract
Background: Interstitial lung disease (ILD) is a crucial issue which impact the prognosis of connective tissue diseased patients and can cause uncontrolled systemic disease activity. So, this work aimed to describe lung functions, radiological abnormalities, and the lung biopsy findings in a group of childhood interstitial lung disease (chILD) caused by underlying connective tissue disease. Methods: Retrospective analysis, diagnostic modalities of chILD in 40 CTD children (JSLE, JIA, JDM, JSS, JMCTD) were evaluated; clinical manifestation, chest imaging (x-ray, HRCT) and lung biopsy in selected cases. Moreover, Spirometer Pulmonary function testing (PFT), 6-minute walk test (6MWT), and transthoracic echocardiography were also evaluated to assess severity and follow up. Histopathological analysis for H&E sections were applied. Results: For ILD associated with juvenile CTD, HRCT was the gold standard for diagnosis and diminish need for lung biopsy with common finding was widespread irregular interlobular septal thickening, ground-glass attenuation, ILD severity showed statistically significant with pulmonary function test and 6-minute walk test parameter. Conclusions: For early prediction and follow up of development of ILD in CTD children, it is recommended to do routine checks of PFT even in the lack of respiratory warning sign, while HRCT is the gold standard to confirm and specify diagnosis.
- Subjects
INTERSTITIAL lung diseases; PULMONARY function tests; CONNECTIVE tissue diseases; LUNG biopsy; HISTOPATHOLOGY
- Publication
Zagazig University Medical Journal, 2022, Vol 28, Issue 6, p1356
- ISSN
1110-1431
- Publication type
Article
- DOI
10.21608/zumj.2021.44366.1955