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- Title
THE INCREASE IN THE PHOTODYNAMIC POTENTIAL OF DACARBAZINE AS A RESULT OF PH DEPENDENCE.
- Authors
COMAN, Ana-Maria; FUMĂREL, Radu; BUDAŞCU, Valentin; ALEXANDRU, Diana Mihaela
- Abstract
Photostimulated chemotherapy (PSChT) is a relatively new therapeutic method whose principle is based on increasing the therapeutic index of certain cytostatics as a result of their interaction with optical radiation. For a particular chemotherapeutic agent to be effective in PSChT-type applications, it must fulfill several conditions, the most important of which is to have a positive photodynamic potential that consists in the resonant transfer of energy between the irradiation source and its molecule. In this study, Dacarbazine (DTIC) was used as the photosensitizing agent, and a highpressure mercury lamp was used as the irradiating agent. Preclinical studies in BL / 6 inbred mice carrying B16 murine melanoma and spectrophotometric determinations were performed to identify whether the DTIC-PSChT method enhances the efficacy of chemotherapy.
- Subjects
DACARBAZINE; ENERGY transfer; MELANOMA; CANCER chemotherapy
- Publication
Lucrari Stiintifice: Seria Medicina Veterinara, 2021, Vol 64, Issue 2, p23
- ISSN
1454-7406
- Publication type
Article