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- Title
Synthesis and Evaluation of Antimicrobial Activity of New 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide Derivatives.
- Authors
Dilsiz Aytemir, Mutlu; Demir Erol, Dilek; Hider, Robert Charles; Özalp, Meral
- Abstract
The synthesis of a range of 3-hydroxy-4-oxo-4H-pyran-2-carboxamide with antimicrobial activity is described. Amide derivatives of pyranone were synthesised using TBTU [2- (1H-benzotriazol-1-yl)- 1,1,3,3-tetramethyluronium tetrafluoroborate] as a coupling agent and NMM (N-methylmorpholine) as a base. Antimicrobial activities were determined as MIC values using the microdilution broth method against Staphylococcus aureus, Entrococcus faecalis, Escherichia coli and Pseudomonas aeruginosa for bacteria and Candida albicans, C. krusei and C. parapsilosis for fungi. 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-[N-(4'-methylcoumarin-7-yl)carboxamide] (8c) exhibited higher antibacterial activity against S. aureus, E. faecalis and E. coli than the other compounds. In addition, 8c was more active against C. krusei than the other synthesised compounds.
- Subjects
ANTI-infective agents; STAPHYLOCOCCUS aureus; ESCHERICHIA coli; PSEUDOMONAS aeruginosa; CANDIDA albicans; CHEMISTRY
- Publication
Turkish Journal of Chemistry, 2003, Vol 27, Issue 6, p757
- ISSN
1300-0527
- Publication type
Article