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- Title
Intraocular pressure changes during intravitreal aflibercept injection based on treat-and-extend regimen in Japanese patients with neovascular age-related macular degeneration and glaucoma.
- Authors
Honjo, Junichiro; Mukai, Ryo; Itagaki, Kanako; Tanaka, Keiichiro; Norikawa, Koki; Kato, Yutaka; Kasai, Akihito; Sugano, Yukinori; Sekiryu, Tetsuju
- Abstract
Purpose: To assess the changes in intraocular pressure (IOP) after intravitreal aflibercept injections in Japanese patients with neovascular age-related macular degeneration (nAMD) complicated by glaucoma. Study design: Retrospective observational study. Methods: We retrospectively reviewed 27 eyes of 25 Japanese patients diagnosed with nAMD complicated by glaucoma. The patients were treated with 2 mg/0.05 ml of aflibercept and followed for 52 weeks according to a treat-and-extend (TAE) regimen after 3 consecutive monthly injections. The IOP of each eye was measured at each visit using non-contact tonometry. IOP changes as well as additional glaucoma treatments during 52 weeks were recorded. Results: The mean of aflibercept injections was 8.3 ± 1.9. The mean IOP at baseline was 14.0 ± 3.1 mmHg, and the mean IOP after aflibercept therapy was 13.0 ± 2.4 mmHg at the final visit (P = 0.0463). No patients received additional glaucoma treatment of eye drops or surgery. Conclusion: Our results suggest that intravitreal aflibercept injections may be beneficial for patients with nAMD complicated by glaucoma.
- Subjects
MACULAR degeneration; INTRAVITREAL injections; INTRAOCULAR pressure; JAPANESE people; TONOMETRY; GLAUCOMA; TONOMETERS
- Publication
Japanese Journal of Ophthalmology, 2024, Vol 68, Issue 2, p91
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-023-01041-3