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- Title
Effect of vitreomacular adhesion on antivascular endothelial growth factor therapy for macular edema secondary to branch retinal vein occlusion.
- Authors
Terao, Ryo; Yuda, Kentaro; Kure, Kayo; Inoue, Tatsuya; Ohtsu, Hiroshi; Yanagi, Yasuo
- Abstract
Purpose: To investigate the association between vitreomacular adhesion (VMA) and the visual and anatomic outcomes of antivascular endothelial growth factor therapy for macular edema due to branch retinal vein occlusion (BRVO). Methods: This study included 107 eyes of 107 patients with BRVO who underwent intravitreal injection of 1.25 mg bevacizumab. The presence of VMA was determined with spectral-domain optical coherence tomography (SD-OCT). All eyes underwent best-corrected visual acuity (BCVA) and central retinal thickness (CRT) measurements using SD-OCT immediately before the injection and at 3, 6, 9, and 12 months after the injection. The main outcome measures were changes in BCVA and CRT from baseline. Results: The VMA(+) and VMA(−) groups consisted of 47 and 60 eyes, respectively, and patients' age differed significantly between the groups ( P < 0.001). In both groups, BCVA and CRT improved after the injection. The VMA(+) group showed better improvement in BCVA than did the VMA(−) group ( P = 0.0150), and the presence of VMA was associated with a greater decrease in CRT after adjusting for age ( P = 0.0019). Conclusions: Presence of VMA may be associated with superior visual and anatomic outcome for intravitreal bevacizumab in the treatment of macular edema due to BRVO.
- Subjects
VASCULAR endothelial growth factors; OPTICAL coherence tomography; BEVACIZUMAB; VISUAL acuity; RETINAL diseases; RETINAL degeneration
- Publication
Japanese Journal of Ophthalmology, 2014, Vol 58, Issue 2, p139
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-013-0302-4