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- Title
Primary Solid Pseudopapillary Tumor of the Ovary: A Case Report and Review of the Literature.
- Authors
Lee, Juhun; Song, Seung Ho; Lee, In Hee; Kim, Dong Ja; Lee, Hyun Jung
- Abstract
Introduction: Solid pseudopapillary neoplasms (SPNs) are rare and mainly originate from the pancreas. SPNs originating from the ovary (SPN-O) are extremely rare, and only 13 cases have been reported in the English literature since 2010. Case: We report a 31-year-old woman with SPN-O accompanied by multiple metastases in the abdominal cavity. The patient underwent staging surgery and cytoreduction. Furthermore, the multidisciplinary board decided on adjuvant chemotherapy with an FP regimen (fluorouracil plus cisplatin) because a microscopic metastasis was discovered in the peritoneum near the appendix. Next-generation sequencing showed some pathologic mutations of oncogenes/cancer-associated genes, including CTNNB1 and TP53. This is the fourteenth case of SPN-O and the first one to demonstrate the TP53 pathogenic mutant variant in SPN-O. The patient showed 8 months of disease-free survival until February 2024. Conclusion: The combination of R0 cytoreduction with FOLFIRI chemotherapy appears to be an effective and feasible treatment option.
- Subjects
LITERATURE reviews; OVARIAN tumors; ADJUVANT chemotherapy; CYTOREDUCTIVE surgery; ABDOMEN
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 10, p2791
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13102791