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- Title
腹腔镜与开腹胰十二指肠切除术治疗胰头癌的疗效对比及术后肿瘤 早期复发的随访研究.
- Authors
刘建平; 杨兴建; 胡毅; 罗超; 刘涛1 李懋
- Abstract
Objective: To compare the efficacy of laparoscopic and open pancreatoduodenectomy in the treatment of pancreatic head cancer, and to analyze the influencing factors of early tumor recurrence after surgery. Methods: From March 2019 to April 2020, 15 cases of general surgery of West China Airport Hospital of Sichuan University and 65 cases of pancreatic surgery of West China Hospital of Sichuan University were selected, a total of 80 patients with pancreatic head cancer were selected according to different surgical methods. There were 32 cases and 48 cases in the laparotomy group and the minimally invasive group, respectively. Perioperative clinical indicators, incidence of complications, and early tumor recurrence rate during follow-up were compared between the two groups. Multivariate Logistic regression was used to analyze the influencing factors of early postoperative recurrence. Results: The operation time of the minimally invasive group was longer than that of the laparotomy group, the hospitalization cost was more than that of the laparotomy group, the intraoperative blood loss was less than that of the laparotomy group, the time of getting out of bed, the time of postoperative exhaust, the time of starting to eat, and the duration of postoperative hospital stay Shorter than laparotomy group (P<0.05). There was no difference in the incidence of complications between the two groups (P>0.05). There was no significant difference in the early tumor recurrence rate between the two groups after surgery (P>0.05). The results of univariate analysis showed that the relationship between early tumor recurrence and age, maximum tumor diameter, lymph node metastasis, vascular tumor thrombus, nerve invasion, preoperative albumin, preoperative carbohydrate antigen 125 (CA125), preoperative carcinoembryonic antigen (CEA) level, postoperative radiotherapy and chemotherapy (P<0.05). Multivariate Logistic regression analysis showed that lymph node metastasis, vascular tumor embolus, nerve invasion, no postoperative radiotherapy and chemotherapy, and high preoperative CA125 level were risk factors for early tumor recurrence in patients with pancreatic head carcinoma (P<0.05). Conclusion: Compared with traditional open surgery, laparoscopic pancreaticoduodenectomy for pancreatic head cancer can shorten the hospital stay and promote postoperative recovery, but the incidence of complications and early postoperative recurrence rate No significant difference. The early tumor recurrence of pancreatic head cancer is affected by many factors such as lymph node metastasis, vascular tumor embolus, nerve invasion, postoperative radiotherapy and chemotherapy, and preoperative CA125 level.
- Subjects
PANCREATIC cancer; SURGICAL blood loss; PANCREATIC surgery; LYMPHATIC metastasis; DISEASE relapse; LOGISTIC regression analysis; CA 125 test
- Publication
Progress in Modern Biomedicine, 2022, Vol 22, Issue 23, p4531
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2022.23.026