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- Title
血小板分布宽度和血小板平均体积在慢性阻塞性肺疾病合并肺动脉高压患者中的临床意义
- Authors
王政权; 李 刚; 杨绍波; 秦韶曦; 张 敏; 樊 杰; 邹蓉蓉
- Abstract
Objectives The goal of this study was to analyze the clinical significance of platelet distribution width (PDW) and mean latelet volume (MPV) levels in the prognosis of chronic obstructive pulmonary disease (COPD) combined with pulmonary artery hypertension (PAH) . Methods In a retrospective study, we identified 498 patients with COPD from January 2012 to December 2013 in the second people's hospital of Qujing,216 of them combined with PAH. We recorded the clinical data, results of blood gas analysis and echocardiography and measured the levels of PDW,MPV and NT-proBNP after admission. The results were statistically analyzed by the statistical package for social sciences (SPSS version 18.0) and software SAS JMP 9.0. Results The levels of PDW [(17.9±1.9%) vs (16.9±2.3) %, =0.008], MPV [(13.9±1.5) fL vs (12.4 ±2.1) fL, = 0.002] and NT-proBNP [(1521.4±925.7) pg/mL vs (691.9±364.5) pg/mL, <0.001] in COPD with PAH group were significantly higher than those in COPD without PAH group. At follow up of 12 months, patients with readmission or death had higher values of PDW [(19.1 ±1.8) % vs (17.6 ±1.4) % , <0.001] and MPV [(14.5 ±1.5) fL vs (13.7 ±1.4) fL, =0.002] . Kaplan-Meier survival analysis showed that the rate of readmission and death after 12 months was significantly higher in patients with higher values of PDW ( =0.018)and MPV ( =0.016) . Conclusions The detection of PDW and MPV has great signification for the prediction of long-term outcomes in COPD combined with PAH.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2016, Vol 37, Issue 3, p100
- ISSN
2095-610X
- Publication type
Article