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- Title
افزایش اثر ضد قارچی نانو ذرات سلنیوم بیوسنتز شده با استفاده از آسپرژیلوس فومیگاتوس.
- Authors
حمید صادقیان; حسین زرینفر; هادی صفدری; محمدحسین احمدی; مائده طهان; مهدی حسینی بافق
- Abstract
Introduction: Green synthesis as a new method of synthesis of nanoparticles with a simple, biocompatible, safe, and economical approach can be an alternative to chemical and physical processes. Fungi can convert some toxic ions into less harmful forms, including nanoparticles. Nanoparticles with a size of 1 to 100 nanometers have unique quantum properties. Today, the problems of drug resistance have been seen in different species of fungi. Selenium nanoparticles (SeNPs) are substances that have been reported to have antifungal properties. The present study aimed to investigate the antifungal effect of biosynthesized SeNPs using Aspergillus fumigatus. Methods: For this purpose, SeNPs were biosynthesized with a specific concentration using A. fumigatus. The presence of nanoparticles was confirmed by various methods, including UV-Vis, FT-IR, FE-SEM, EDX, XRD, DLS, and Zeta potential. Then, susceptibility determination based on the Minimum Inhibitory Concentration (MIC) test was performed on standard fungal strains treated with SeNPs. Results: After confirming the results of nanoparticle biosynthesis, the MICs for Itraconazole and Amphotericin B against the standard fungal strains were 8 and 4 μg/mL respectively. In comparison, MIC values for SeNPs-treated samples were reduced to 1 μg/mL and below. Conclusion: Due to the increasing resistance of opportunistic fungi to target antifungal drugs, the use of biosafety SeNPs even at low concentrations can have favorable inhibitory effects on the growth of fungal pathogens.
- Subjects
CHEMICAL processes; NANOPARTICLE size; ASPERGILLUS fumigatus; AMPHOTERICIN B; ZETA potential
- Publication
Knowledge & Health / Dānish va Tandurustī, 2022, Vol 17, Issue 3, p40
- ISSN
1735-577X
- Publication type
Article
- DOI
10.22100/jkh.v17i3.3077