We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diagnostic potential of tumor DNA from ovarian cyst fluid.
- Authors
Yuxuan Wang; Sundfeldt, Karin; Mateoiu, Constantina; Ie-Ming Shih; Kurman, Robert J.; Schaefer, Joy; Silliman, Natalie; Kinde, Isaac; Springer, Simeon; Foote, Michael; Kristjansdottir, Björg; James, Nathan; Kinzler, Kenneth W.; Papadopoulos, Nickolas; Diaz, Luis A.; Vogelstein, Bert
- Abstract
We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non-neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions.
- Subjects
OVARIAN cysts; GENETIC mutation; TUMOR diagnosis; CANCER genetics; BODY fluids
- Publication
eLife, 2016, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.15175