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- Title
miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma.
- Authors
SHAOHUA WANG; KE CAO; QUANYONG HE; ZHAOQI YIN; JIANDA ZHOU
- Abstract
A growing quantity of evidence exists to suggest that microRNAs are significant regulators of multiple cellular processes. When expressed aberrantly in different types of cancer, including cutaneous squamous cell carcinoma (cSCC), they play key roles in tumorigenesis and progression. The aberrant expression of miR-199a-5p has been observed to contribute to carcinogenesis in various types of cancer. However, the role of miR-199a-5p in the progression of cSCC metastasis remains largely unknown. In this study, we determined that miR-199a-5p was the upstream regulator of CDH1 (E-cadherin) and that it could suppress the expression of E-cadherin in cSCC cells. In addition, miR-199a-5p mimics significantly induced cell invasion and the activity of matrix metalloproteinase (MMP)2 and MMP9 in cSCC cells. In conclusion, these results are likely to aid in elucidating the molecular mechanisms of cSCC progression. In addition, the findings provide a new theoretical basis to further investigate miR-199a-5p as a potential biomarker and a promising approach in cSCC treatment.
- Subjects
MICRORNA; SQUAMOUS cell carcinoma; NEOPLASTIC cell transformation; CANCER invasiveness; CADHERINS; CARCINOGENESIS
- Publication
Oncology Letters, 2016, Vol 12, Issue 1, p97
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4602