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- Title
Ablation of the circadian rhythm protein CACNA2D3 impairs primordial follicle assembly in the mouse ovary.
- Authors
Liu, Wen‐Xiang; Xie, Xin‐Xiang; Yan, Hong‐Chen; Klinger, Francesca Gioia; Dri, Maria; Felici, Massimo De; Shen, Wei; Wang, Bin‐Bin; Cheng, Shun‐Feng
- Abstract
This article explores the role of the circadian rhythm protein CACNA2D3 in the assembly of primordial follicles in the mouse ovary. The study used single-cell RNA sequencing to investigate the impact of CACNA2D3 knockout on ovarian development and fertility in female mice. The results showed that CACNA2D3 knockout led to smaller ovaries and a lower number of follicles, particularly primordial follicles. The study also identified changes in gene expression related to energy metabolism, circadian rhythm, and cell-cell communication in oocytes and pregranulosa cells. Further research is needed to understand the underlying mechanisms and potential therapeutic targets for primary ovarian insufficiency.
- Subjects
CIRCADIAN rhythms; OVARIES; MICE; RNA sequencing; ENERGY metabolism
- Publication
Clinical & Translational Medicine, 2023, Vol 13, Issue 11, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1467