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- Title
Absence of cyclin-D2 and Bcl-2 expression within the germinal centre type of diffuse large B-cell lymphoma identifies a very good prognostic subgroup of patients.
- Authors
Amen, F.; Horncastle, D.; Elderfield, K.; Banham, A. H.; Bower, M.; Macdonald, D.; Kanfer, E.; Naresh, K. N.
- Abstract
Aims: To validate and improve the existing algorithm (proposed by Hans et al.) to classify diffuse large B-cell lymphoma (DLBCL). Methods and results: Tissue microarrays constructed from 81 patients with DLBCL were studied by immunohistochemistry for expression of CD10, Bcl-6, MUM1, Bcl-2, cyclin-D2, FOXP1 and PKC-γ proteins. Cases were classified as either germinal centre B-like (GCB) or non-GC according to Hans et al. An alternative classification was also employed, in which cases positive for either CD10 or Bcl-6 were considered as a GC subgroup and cases negative for both CD10 and Bcl-6 were considered as a non-GC subgroup. GC was further subdivided into favourable GC (negative for both Bcl-2 and cyclin-D2) and unfavourable GC (positive for either Bcl-2 or cyclin-D2). The 5-year event-free survival (EFS) amongst patients classified as favourable GC versus ‘others’ was 49.5% and 7.3%, respectively (log rank P < 0.0001). Similarly, the 5-year overall survival (OS) amongst patients classified as favourable GC versus ‘others’ was 58.6% and 13.7%, respectively (log rank P = 0.0001). The difference in survival was independent of the international prognostic index. Conclusions: In this group of patients the risk stratification based on the new algorithm was better than that proposed by Hans et al.
- Subjects
MEDICAL research; LYMPHOMAS; CANCER patients; IMMUNOHISTOCHEMISTRY; GERMINAL centers; PROGNOSTIC tests
- Publication
Histopathology, 2007, Vol 51, Issue 1, p70
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2007.02721.x