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- Title
COVID‐19 vaccines and anaphylaxis—evaluation with skin prick testing, basophil activation test and Immunoglobulin E.
- Authors
Csuth, Àgnes; Nopp, Anna; Storsaeter, Jann; Nilsson, Lennart; Jenmalm, Maria C.
- Abstract
Keywords: anaphylaxis; basophil activation test; COVID-19; polyethylene glycol; skin prick test; vaccine EN anaphylaxis basophil activation test COVID-19 polyethylene glycol skin prick test vaccine 812 819 8 06/01/22 20220601 NES 220601 Key Messages Skin prick tests were negative in our patients with reported anaphylaxis to the first dose of mRNA vaccine against COVID-19. Six of the patients (patient number: 22-27/Table 1) reacted with acute onset (within 10-60 min after the first dose) skin symptoms such as urticaria or generalized erythema with or without pruritus with no other objective symptoms. Ten patients were evaluated due to a previous severe reaction to medications, that is, injectable medicines containing PEG/PEG derivatives, which raised suspicion of a PEG/PEG-derivative allergy (patient number: 28-37/Table 2). To end the devastating COVID-19 pandemic and limit mortality, as many as possible need to be safely vaccinated.10 Patients with acute onset vaccine-related systemic reactions to the first COVID-19 vaccine dose, or suspected PEG allergy, should be referred to an allergist or allergy-interested physician.
- Subjects
IMMUNOGLOBULIN E; COVID-19 vaccines; URTICARIA; SKIN tests; MILK allergy; ANAPHYLAXIS
- Publication
Clinical & Experimental Allergy, 2022, Vol 52, Issue 6, p812
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.14143