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- Title
Withdrawal from chronic morphine administration causes prolonged enhancement of immobility in rat forced swimming test.
- Authors
Anraku, Tsuyoshi; Ikegaya, Yuji; Matsuki, Norio; Nishiyama, Nobuyoshi
- Abstract
Rationale: Opiate-dependent subjects experience severe depression as one of the subjective symptoms during withdrawal. No experimental work, however, has focused on the ability of opiate-withdrawal to produce depression-like behavior in dependent animal. Objectives: We therefore investigated whether withdrawal from chronic morphine treatment affects immobility in forced swimming test in rats. Methods: Morphine was administered in a dose escalation fashion using doses ranging from 20 to 140 mg/kg twice daily for 14 days, followed by 1–6 days of withdrawal, and their duration of immobility was assessed. Results: After the last morphine treatment, an increase in immobility occurred late on day 3 and persisted to at least day 6 of withdrawal without any change in ambulatory activity. Conclusions: The results suggest that the morphine withdrawal resulted in prolonged enhancement of depression-like behavior in drug-dependent laboratory animals.
- Subjects
DRUG withdrawal symptoms; MORPHINE; DRUG administration
- Publication
Psychopharmacology, 2001, Vol 157, Issue 2, p217
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130100793