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- Title
Histopathological Assessment of Liver Biopsy Specimen in the Context of HBV DNA and HBeAg in Patients with Chronic Hepatitis B.
- Authors
Nahar, Naznin; Mamun-Al-Mahtab; Nahar Rahman, A. J. E.; Fazle Akbar, Sheikh Mohammad; Habib, Saequa
- Abstract
Background: There is lack of consensus if hepatitis B virus (HBV) DNA can be regarded as a surrogate marker of liver damages in patients with chronic hepatitis B (CHB). Methods: A total of 77 patients with CHB were enrolled in this study. The sera of the patients were tested for HBV DNA and hepatitis B e antigen (HBeAg). The extent of hepatitis and hepatic fibrosis was assessed by liver biopsy. Results: Out of total of 77 patients with CHB, 29 were HBeAg-positive and 48 were HBeAg-negative. Twenty-seven of 29 HBeAg-positive patients and eight of 48 HBeAg-negative patients had high levels of HBV DNA (HBV DNA>105 copies/ml). The extent of hepatitis was minimal or mild in most HBeAg-positive CHB patients (27 of 29) irrespective of the levels of HBV DNA in the sera. Moderate levels of hepatitis were seen in two HBeAg-positive patients and five HBeAg-negative patients. Moderate levels of hepatic fibrosis were seen in four of eight HBeAg-negative patients with high HBV DNA. Conclusion: This study shows that HBV DNA and HBeAg do not reflect the extent of hepatitis or hepatic fibrosis in CHB patients of Bangladesh. Combination of different HBV-related markers with liver biopsy is required for proper diagnosis and management of CHB in Bangladesh. Abbreviations: HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; ALT: Alanine aminotransferase; CHB: Chronic hepatitis B; HAI: Histology activity index.
- Subjects
HEPATITIS B; DNA; VIRAL hepatitis; BLOOD plasma; HEPATITIS viruses
- Publication
Euroasian Journal of Hepato-Gastroenterology, 2011, Vol 1, Issue 2, p83
- ISSN
2231-5047
- Publication type
Article
- DOI
10.5005/jp-journals-10018-1018