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- Title
EFFICACY OF DEXAMETHASONE PULSE THERAPY IN PROGRESSIVE SYSTEMIC SCLEROSIS.
- Authors
Pai, Ballambat Sathish; Srinivas, Chakravarthi R.; Sabitha, Lakshminarayanan; Shenoi, Shrutakirthi D.; Balachandran, Chandrasekharan N.; Acharya, Sandhya
- Abstract
<em>Background</em>. Systemic sclerosis is a disease of unknown etiology for which no specific treatment is effective. Pulse therapy with corticosteroids has been tried for various autoimmune disorders with minimal side effects. We under- took this study to determine the efficacy of dexamethasone pulse therapy in progressive systemic sclerosis (PSS). <em>Methods</em>. Five women with PSS between the ages 30 and 60 years, received 100 mg dexamethasone in 500 mL of 5% dextrose by slow intravenous infusion over 3 hours for 3 consecutive days, once a month. <em>Results</em>. All patients had symptomatic and clinical improvement. The vital capacity improved in three and posttreatment histopathologic regression was seen in two patients. <em>Conclusions</em>. Dexamethasone pulse therapy may provide an additional option for treating systemic sclerosis.
- Subjects
SYSTEMIC scleroderma; COLLAGEN diseases; ADRENOCORTICAL hormones; STEROID hormones; DEXTROSE; REGRESSION analysis
- Publication
International Journal of Dermatology, 1995, Vol 34, Issue 10, p726
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/j.1365-4362.1995.tb04664.x