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- Title
The Effect of Renal Transplantation on Respiratory Muscle Strength in Patients with End-Stage Renal Disease.
- Authors
Mirzaei, M.; Mirzaei, S.; Sepahvand, E.; Nasimi, F.
- Abstract
Background: The respiratory system is affected in patients with chronic kidney disease. Not only does renal failure, itself, but also the necessary therapeutic procedures, such as peritoneal dialysis or hemodialysis, affect the respiratory system. These patients usually have decreased protein calorie reception that results in muscular atrophy and protein imbalance. Calcification of the respiratory muscles results in abnormal spirometry findings. Objective: To evaluate the respiratory muscle strength in patients with chronic kidney disease before and after transplantation. Methods: This study is a review article provided by library and the Internet resources. Results: The commonest application test to evaluate the respiratory muscle strength is measuring PIMAX (diaphragm and other inspiratory muscles strength index) and PEMAX (expiratory muscle strength index). Many studies have shown an increase in PIMAX and PEMAX in 30 to 90 days after renal transplantation, which is due to removal of uremic effect on respiratory muscles. Also, some studies showed that the residual volume and total lung capacity in patients undergoing hemodialysis or peritoneal dialysis is more than transplanted patient that would be attributed to the inflated lung due to small respiratory duct involvement. This problem improved greatly after transplantation. On the other hand, since PIMAX and PEMAX above 60% is considered normal, some studies assert that despite improvements in maximal inspiratory and expiratory pressure after transplantation, these parameters were less than 60% that showed that even after a successful kidney transplant, there is still degrees of muscle weakness. This has been attributed to immunosuppressive therapy such as corticosteroids, which led to decreased muscle protein synthesis that prevents full recovery of muscle fibers after kidney transplant. The less mobile lifestyle and lack of systematic rehabilitation program after a kidney transplant may also have negative effects on the outcome. Conclusion: Based on these results, we can conclude that the muscle weakness after kidney transplantation, in patients with chronic kidney disease can be recovered to some extent.
- Subjects
KIDNEY transplantation; RESPIRATORY muscles; CHRONIC kidney failure
- Publication
International Journal of Organ Transplantation Medicine, 2016, Vol 7, Issue 2, p140
- ISSN
2008-6490
- Publication type
Abstract