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- Title
New Cyclic Pentapeptides from the Mangrove-Derived Aspergillus fumigatus GXIMD 03099.
- Authors
Wang, Yu; Cao, Guangping; Gan, Yuman; Lin, Xiao; Yi, Xiangxi; Zhao, Longyan; Liu, Yonghong; Gao, Chenghai; Bai, Meng
- Abstract
Four new cyclic pentapeptides, avellanins D–G (1–4), together with four known compounds (5–8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus from Acanthus ilicifolius L. Their structures were elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. Their absolute configurations were determined by X-ray diffraction analysis and Marfey's method. Compounds 1–8 were screened for insecticidal and antibacterial activities. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with an LC50 value of 86.6 µM; compound 4 had weak activity against Vibrio harveyi with an MIC value of 5.85 µM.
- Subjects
ASPERGILLUS fumigatus; CULEX quinquefasciatus; VIBRIO harveyi; X-ray diffraction; ANTIBACTERIAL agents; VIBRIO anguillarum
- Publication
Marine Drugs, 2024, Vol 22, Issue 6, p282
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22060282