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- Title
Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation.
- Authors
Pişkin, Özcan; Aydın, Bengü Gülhan; Baş, Yılmaz; Karakaya, Kemal; Can, Murat; Elmas, Özlem; Büyükuysal, Mustafa Çağatay
- Abstract
Aim: The aim of this study was to evaluate the protective use of quercetin in a rat model of radiation-induced enteritis and colitis. Methods: Twenty four adult rats were randomly divided into four groups. Group SHAM was given only physiological saline, group QUER was given quercetin 50 mg/kg for 15 days, group RAD was given only irradiation and group QUER+RAD was given quercetin 50 mg/kg, and then irradiated. Twenty four hours after the exposure to radiation, all rats were euthanized for the evaluation of the ileum and colon morphology and biochemical measurements. Results: Compared with the SHAM group, the serum malondialdehyde (MDA) level was significantly higher in group RAD (p=0.004) and was significantly decreased in group QUER+RAD (p=0.015). The MDA levels in the ileum and colon tissues were significantly higher in group RAD (p=0.004 and p=0.002, respectively), while treatment with quercetin significantly reduced lipid peroxidation in both tissues in group QUER+RAD (p=0.015 and p=0.009, respectively). Compared with the control group, the serum total antioxidant status (TAS) level was significantly lower in Group RAD (p=0.002) and was significantly increased in group QUER+RAD (p=0.009). TAS in the ileum and colon tissues were significantly lower in group RAD (p=0.002 and p=0.002) and were significantly higher in both tissues in group QUER+RAD (p=0.002 and p=0.002, respectively). Conclusion: This study confirmed that, in the model of radiation-induced ileitis and colitis in rats, quercetin effectively decreased oxidative stress and inflammatory damage to both ileum and colon tissues.
- Subjects
ANIMAL experimentation; ANTIOXIDANTS; BIOLOGICAL models; COLITIS; COMPARATIVE studies; ENTERITIS; INTESTINAL mucosa; LIPID peroxidation (Biology); HEALTH outcome assessment; QUERCETIN; RADIATION; RATS; STATISTICAL sampling; MALONDIALDEHYDE
- Publication
Medical Bulletin of Haseki / Haseki Tip Bulteni, 2018, Vol 56, Issue 1, p14
- ISSN
1302-0072
- Publication type
Article
- DOI
10.4274/haseki.25743