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- Title
Cefepime Induced Neurotoxicity: Case Series.
- Authors
DAS, SUKANTO KISHORE; DAS, SUBODH KUMAR; PANDA, AKHILA; PARHI, LAXMIDHAR
- Abstract
Cefepime is a broad-spectrum antimicrobial which is widely used for the treatment of both gram positive and gram negative pathogens, mainly in hospital setup for critically ill patients. Its half-life is around two hours and is primarily excreted via kidneys. However, in patients with renal impairment the half-life increases up to 13 hours. This may cause drug accumulation leading to several toxicities, of which neurotoxicity is of prime concern. Missing the diagnosis of these symptoms related to cefepime it may lead to increase in mortality or central nervous system dysfunction. Dose adjustment is recommended in such cases; however, several reports of neurological manifestations have been documented despite such modification. Here, is a series of six cases of cefepime induced neurotoxicity. The symptoms that the patients reported with were drowsiness, disorientation, non-convulsive epilepsy, slurred speech, tremors and myoclonic jerks. In all patients, cefepime was withdrawn and symptomatic management with anti-epileptic drug and monitoring with repeat Electroencephalogram (EEG) were done.
- Subjects
CEFEPIME; NEUROTOXICOLOGY; EPILEPSY; DRUG monitoring; ANTICONVULSANTS; DIAGNOSIS
- Publication
Journal of Clinical & Diagnostic Research, 2021, Vol 15, Issue 6, p1
- ISSN
0973-709X
- Publication type
Article
- DOI
10.7860/JCDR/2021/49031.15045