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- Title
SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL ACTIVITIES OF NAPHTHO[2,1-b]FURAN DERIVATIVES.
- Authors
Nagarsha, K. M.; Sharanakumar, T. M.; Ramesh, D.; Kumarswamy, M. N.; Latha, K. P.
- Abstract
The naphthofuran and its derivatives are important biological compounds so we have focused on the synthesis of naphthofuran derivatives. The synthesized compounds of ethyl 1-(acetylamino)-5-nitronaphtho[2,1-b]furan-2- carboxylate (3), and N-[2-(hydrazinylcarbonyl)-5-nitronaphtho[2,1-b]furan-1-yl]acetamide (4) used for the synthesis of N-(2-{[(2Z)-2-benzylidenehydrazinyl]carbonyl}-5-nitronaphtho[2,1-b]furan-1-yl)acetamide compounds of four derivatives 5 (a-d) and 1-acetamido-5-nitro-N-(5-oxo-2-phenylthiazolidin-3-yl)naphtha[2,1-b]furan-2-carboxamide compounds of four derivatives 6 (a-d). The prepared compounds were confirmed by FTIR NMR, and mass methods. The prepared naphthofuran derivatives used for the antibacterial activity versus both Gram(+ve) and Gram(-ve) bacteria show excellent results. Therefore the synthesized compounds are used for further antibacterial studies in the medical field.
- Subjects
ACETAMIDE derivatives; ANTIBACTERIAL agents; FURAN derivatives; CHEMICAL synthesis; ACETAMIDE; NAPHTHA
- Publication
Rasayan Journal of Chemistry, 2022, Vol 15, Issue 4, p2477
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2022.1548052