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- Title
SILICASUPPORTED COPPER(II) OXIDE FOR THE SYNTHESIS OF CURCUMIN DERIVATIVES CONTAINING PYRAZOLE AND ISOXAZOLE SCAFFOLDS.
- Authors
Cahyana, Antonius Herry; Ardiansah, Bayu; Ibrahim, Wahyu Hidayat
- Abstract
Preparation of CuO/SiO2catalyst has been done via sol-gel method using copper nitrate solution and TEOS as precursors. Several instruments such as FT-IR, SEM, EDAX, XRD and particle sizer were employed to characterize the obtained material. Then, CuO/SiO2 catalyst was successfullyusedin the synthesis of three curcumin derivatives, 4,4'-((1E,1'E)-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 1), 4,4'-((1E,1'E)-(1-phenyl-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 2) and 4,4'-((1E,1'E)- (isoxazole-3,5-diylbis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 3) with good yields.
- Subjects
CURCUMINOIDS; OXIDE synthesis; PYRAZOLE derivatives; ISOXAZOLES; COPPER; SOL-gel processes
- Publication
Rasayan Journal of Chemistry, 2019, Vol 12, Issue 2, p471
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2019.1225011