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- Title
SYNTHESIS AND BIOLOGICAL INVESTIGATION OF 3,3,6,6-TETRAMETHYL-9-STYRYL-1,8-DIOXOOCTAHYDROXANTHENE PROMOTED BY Fe<sub>3</sub>O<sub>4</sub>-SUPPORTED CITRIC ACID AS A MAGNETICALLY RECOVERABLE CATALYST.
- Authors
Cahyana, A. H.; Pratiwi, D.; Ardiansah, B.
- Abstract
A green and attractive protocol was developed to produce 3,3,6,6-tetramethyl-9-styryl-1,8-dioxooctahydroxanthene using magnetically separable Fe3O4 modified by citric acid (Fe3O4-CA) as catalyst. After catalyst characterization using XRD, Particle Sizer, SEM and EDAX, the Fe3O4-CA was then applied in dioxooctahydroxanthene synthesis with several optimizations, such as % wt. of catalyst, reaction time, temperature and solvent. The best protocol was found when the reaction is conducted using 5% wt. of catalyst at 50°C for 6 h reaction time in methanol, with the highest yield of 80%. The product obtained was confirmed by FTIR, UV-Vis, LC-MS, 1H- and 13C-NMR analysis. In biological investigation, dioxooctahydroxanthene showed higher radical scavenging activity with IC50 of 24.17 ppm, whereas it has comparable antibacterial activity than cinnamaldehyde as its precursor.
- Subjects
TETRAMETHYL compounds; CITRIC acid; CATALYSTS recycling; X-ray diffraction; STYRYL compounds
- Publication
Rasayan Journal of Chemistry, 2016, Vol 9, Issue 4, p896
- ISSN
0974-1496
- Publication type
Article