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- Title
Synthesis of Azobenzene Dyes Mediated by CotA Laccase.
- Authors
Sousa, Ana Catarina; Baptista, Sara R.; Martins, Lígia O.; Robalo, M. Paula
- Abstract
An eco‐friendly protocol for the synthesis of azobenzene dyes by oxidative coupling of primary aromatic amines is reported. As efficient biocatalytic systems, CotA laccase and CotA laccase/ABTS (2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid)) enable the oxidation of various substituted anilines, in aqueous medium, ambient atmosphere and under mild reaction conditions of pH and temperature. A series of azobenzene dyes were prepared in good to excellent yields in an one‐pot reaction. A mechanistic proposal for the formation of the azo derivatives is presented. Our strategy offers an alternative approach for the direct synthesis of azobenzene dyes, avoiding the harsh conditions generally required for most of the traditional synthetic methods. Dye another day: A simple and green approach for the synthesis of azo dyes has been developed. CotA laccase, an eco‐friendly catalyst, was used to promote the oxidative coupling of substituted aromatic amines towards the formation of azobenzene dyes, which were obtained in moderate to excellent yields under mild conditions with short reaction times.
- Subjects
LACCASE; AZO compound synthesis; CHEMICAL yield; DYES &; dyeing; AZOBENZENE; BIOCATALYSIS
- Publication
Chemistry - An Asian Journal, 2019, Vol 14, Issue 1, p187
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201801450