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- Title
Synthesis and biological evaluation of 4-(2′,4′-difluorobiphenyl-4-yl)-6-arylpyrimidin- 2-amine derivatives.
- Authors
Fathimunnisa, M.; Manikandan, Haridoss; Neelakandan, K.; Rajendra Prasad, N.; Ganesan, M.
- Abstract
4-(2′,4′-Difluorobiphenyl-4-yl)-6-arylpyrimidin-2-amines 5a-g were synthesized and evaluated for their ability to inhibit various bacterial and fungal strains. The cytotoxicity of the compounds was investigated by a 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay against the Hep-2 cell line. Molecular docking studies were also conducted to locate the binding interaction with the target protein 4LRH.
- Subjects
ARYL group; PYRIMIDINES; CHEMICAL synthesis; DIPHENYL; TETRAZOLIUM compounds
- Publication
Heterocyclic Communications, 2016, Vol 22, Issue 6, p351
- ISSN
0793-0283
- Publication type
Article
- DOI
10.1515/hc-2016-0050