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- Title
Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation.
- Authors
Guillen, Paul O.; Gegunde, Sandra; Jaramillo, Karla B.; Alfonso, Amparo; Calabro, Kevin; Alonso, Eva; Rodriguez, Jenny; Botana, Luis M.; Thomas, Olivier P.
- Abstract
Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (<bold>1</bold>) and 3-acetoxyzoanthamine (<bold>2</bold>), have been isolated from the zoantharian <italic>Zoanthus</italic> cf. <italic>pulchellus</italic> collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of <bold>1</bold> and <bold>2</bold> were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from <italic>Zoanthus</italic> cf. <italic>pulchellus</italic> collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation.
- Subjects
ZOANTHARIA; INFLAMMATION; ANTHOZOA; CORALS; ALKALOIDS
- Publication
Marine Drugs, 2018, Vol 16, Issue 7, p242
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md16070242