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- Title
5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.
- Authors
Fang Fang; Jiaying Zhao; Lijian Ding; Chunhui Huang; Naman, C. Benjamin; Shan He; Bin Wu; Peng Zhu; Qijun Luo; Gerwick, William H.; Xiaojun Yan; Qinwen Wang; Zaijun Zhang; Wei Cui
- Abstract
A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease β-amyloid (Aβ) fibrillization in vitro. Moreover, 1 significantly reduced H2O2-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-Aβ fibrillization properties and neuroprotective effects, and might be a good free radical scavenger.
- Subjects
CYCLOPENTENONE; TRICHODERMA; AMYLOID beta-protein; NEUROPROTECTIVE agents; CIRCULAR dichroism; ISOCOUMARINS
- Publication
Marine Drugs, 2017, Vol 15, Issue 8, p260
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md15080260