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- Title
Serum cystatin is not a marker of glomerular filtration rate in pregnancy.
- Authors
Bramham, Kate; Makanjuola, David; Hussein, Wael; Cafful, Debra; Shehata, Hassan
- Abstract
The role of cystatin C (Cys-C) as a marker of glomerular filtration rate (GFR) in pregnancy is undetermined. Measurements of Cys-C and creatinine (Cr) were taken at 14-17+6, 18-23+6, 27-31+6 weeks' gestation, at delivery and 2-6 weeks postpartum in a prospective observational study of 27 women. There was no difference between Cys-C levels in early and late second trimester, but they were significantly higher in early third trimester (P< 0.001) than second trimester, despite no concurrent increase in Cr. Cys-C was also significantly higher at delivery than at all other times in pregnancy (P< 0.001) and fell to postpartum values higher than second trimester measurements (P< 0.01), but lower than delivery (P<0.001). In conclusion, changes in Cys-C may be influenced by pregnancy-related changes in glomerular filtration and therefore we would advise against their use as a marker of GFR in pregnancy.
- Subjects
CYSTATINS; GLOMERULAR filtration rate; BIOMARKERS; KIDNEY function tests; PREGNANCY; CREATININE; PUERPERIUM; SECOND trimester of pregnancy; BLOOD proteins
- Publication
Obstetric Medicine (1753-495X), 2009, Vol 2, Issue 3, p121
- ISSN
1753-495X
- Publication type
Article
- DOI
10.1258/om.2009.090019