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- Title
Estrogen Receptor α Gene Polymorphisms and Risk of Myocardial Infarction.
- Authors
Schuit, Stephanie C. E.; Oei, Hok-Hay S.; Witteman, Jacqueline C. M.; Geurts van Kessel, Corine H.; Van Meurs, Joyce B. J.; Nijhuis, Rogier L.; Van Leeuwen, Johannes P. T. M.; De Jong, Frank H.; Zillikens, M. Carola; Hofman, Albert; Pols, Huibert A. P.; Uitterlinden, André G.
- Abstract
Presents research to determine if the estrogen receptor α (ESR1) halotype created by the c.454-397T>C (Pvull) and c.454-351A>G (Xbal) polymorphisms is associated with myocardial infarction and ischemic heart disease. Design, setting, participants, main outcome measure and results; Conclusion that postmenopausal women with ESR1 halotype 1 are at increased risk, but no association was observed in men.
- Subjects
GENETIC polymorphisms; MYOCARDIAL infarction risk factors; ESTROGEN receptors; MEDICAL care of older women; CORONARY disease; DISEASE susceptibility; MEDICAL genetics; GENETIC research
- Publication
JAMA: Journal of the American Medical Association, 2004, Vol 291, Issue 24, p2969
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.291.24.2969