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- Title
Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis.
- Authors
Abraham, Edward; Reinhart, Konrad; Opal, Steven; Demeyer, Ignance; Doig, Christopher; Lopez Rodriguez, Angel; Beale, Richard; Svoboda, Petr; Laterre, Pierre Francois; Simon, Stuart; Light, Bruce; Spapen, Herbert; Stone, Judy; Seibert, Allan; Peckelsen, Claus; Sprung, Cathy; Artigas, Antonio; De Deyne, Cathy; Postier, Russell; Pettila, Ville
- Abstract
Discusses the efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis. Lack of effect on all-cause mortality in patients with severe sepsis when treated with tifacogin; Tissue factor as a major initiator of the blood coagulation process; TFPI levels in treatment groups.
- Subjects
SEPSIS; BLOOD coagulation; TISSUES; THROMBOEMBOLISM; MORTALITY
- Publication
JAMA: Journal of the American Medical Association, 2003, Vol 290, Issue 2, p238
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.290.2.238