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- Title
(±)-Pestalachloride D, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp.
- Authors
Wei, Mei-Yan; Dan Li; Shao, Chang-Lun; Deng, Dong-Sheng; Wang, Chang-Yun
- Abstract
A new antibacterial chlorinated benzophenone derivative, (±)-pestalachloride D (1), along with a related analog, (±)-pestalachloride C (2), was recently isolated from the marine-derived fungus Pestalotiopsis sp. isolated from a soft coral Sarcophyton sp. collected from Yongxing Island in the South China Sea. Both chiral HPLC analysis and single-crystal X-ray data indicated that 1 is a racemic mixture. Interestingly, 1 did not exhibit any effect in the zebrafish embryo teratogenicity assay, while 2 led to abnormal growth. The potential impact on zebrafish embryo growth is discussed based on their crystal structures. The main difference of crystal structures between 1 and 2 is that the six-member non-aromatic ring (O4, C10, C9, C8, C2', and C3') in 1 exhibits a distorted chair conformation, while 2 shows a distorted boat conformation. Moreover, compounds 1 and 2 both exhibited moderate antibacterial activity.
- Subjects
ANTIBACTERIAL agents; FUNGI; CORALS; BENZOPHENONES; CHEMICAL derivatives; CHLORINATION; CRYSTAL structure
- Publication
Marine Drugs, 2013, Vol 11, Issue 4, p1050
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md11041050