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- Title
Immunohistochemical study and identification of alpha and beta endocrine cells of the pancreatic islets in goat (Capra hircus).
- Authors
Khaleel, Iman Mousa; Zghair, Fatimah Swadi; Naser, Rabab abd Alameer
- Abstract
A recent study aims at investigating the immunohistochemical and histochemical analysis of adult goat's pancreatic tissue. Histological parts assembled from their pancreas specimens are stained with special and general stains, otherwise recorded and examined with its image software using the Dino-eye piece camera. The endocrine part mainly resides in the Langerhans islet, which is well connected to extra-blood vessels & exocrine ducts. Every islet was constructed microscopically with several cells (alpha and beta) that varied in size, shape, and color. The pancreas is one of the unique endocrine glands, it has endocrine and exocrine secretions. The Islet of Langerhans constitute the endocrine component of the pancreas, its secretory has definite employment for life. A boundary was created by the collagen fibers between the exocrine and endocrine parts. There were oval, circular, or irregular islets based on their scale on its long axis, the form, and were graded into small, medium, and huge. The specific islet cells have specific characteristics and secrete the specific hormone. The Alpha and beta, were the two main cell types and few delta cells were found in Langerhans islets, these different islet cells synthesize and secrete different hormones which need for the biological system to achieve satisfactory metabolic control over blood sugar. The region distribution, the proportional (relative) frequency, and the appearance of glucagon (A-cells)- & glucose-dependent insulinotropic peptide(B-cells)-secreted cells in the endocrine and exocrine pancreas of goat were studied using the immunohistochemical method. Glucagon immunopositive A-cells were principally present in the center and mantle regions of Langerhans islets, whereas glucose-dependent insulinotropic peptide immunopositive B-cells were found in the periphery, center, and mantle of pancreatic islets. Moreover, some A- and B-cells were present as only single cells or clusters of (2 - 3) immunopositive cells in the exocrine parenchyma and the pancreatic duct epithelial cells. The presence, region distribution, and proportional or (relative) frequency of A-&B-cells in goat's pancreas have been analyzed firstly. The immunopositivity and distribution of endocrine cells in the goat pancreas were specified to be partially variable from that of other mammalian species like sheep.
- Subjects
PANCREAS; LANGERHANS cells; BIOLOGICAL systems; METABOLIC regulation; GLUCAGON; ENDOCRINE cells
- Publication
EurAsian Journal of Biosciences, 2020, Vol 14, Issue 2, p6465
- ISSN
1307-9867
- Publication type
Article