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- Title
Natural History and Surgical Management of Oral Malignant Melanoma.
- Authors
Al Salman, Rahmah Hameed; Fageha, Mohammed Essam; Alghamdi, Khalid Abdulrahman S.; Shamlan, Suzan Sulaiman hamad; Talab, Yara Tareq Mohammed; Almalki, Alaa Omar D.; Bardisi, Wajdi Mohammed; Albaradi, Khaled Hamad M.; Alsharif, Majid Gais Faisal
- Abstract
Pigmented entities are relatively common in the oral mucosa and arise from intrinsic and extrinsic sources. Conditions such as melanotic macules, nevi, smoker's melanosis, amalgam and graphite tattoos, racial pigmentation, and vascular blood-related pigments occur with some frequency. Addison disease, Peutz- Jeghers syndrome, and Laugier-Hunziker syndrome also appear in perioral and oral locations as pigmented macules. Detailed knowledge of melanoma at the molecular level allows the development of new treatment alternatives and to design effective new drugs. Addison disease presents as adrenal cortical hypofunction along with splotchy or generalized bronzing of the mucosa and skin. Peutz-Jeghers syndrome has periorificial freckling along with hamartomatous intestinal polyps, and, as a differential diagnosis, Laugier-Hunziker syndrome presents with macular mucocutaneous hyperpigmentation and melanonychia with no known systemic disease association. We conducted this review using a comprehensive search of MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials from January 1, 1970, through February 28, 2017.
- Subjects
MELANOMA treatment; ORAL cancer; ORAL surgery; ORAL mucosa; MOLECULAR pharmacology; DRUG development
- Publication
Egyptian Journal of Hospital Medicine, 2017, Vol 69, Issue 8, p3016
- ISSN
1687-2002
- Publication type
Article
- DOI
10.12816/0042849