We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Studies towards optimising the isolation of diplonine, a neurotoxin isolated from cultures of Stenocarpella maydis (Berk.) Sacc.
- Authors
Snyman, Leendert D.; Flett, Bradley C.; Schultz, Rowina A.
- Abstract
Diplonine, a mycotoxin that induces neurotoxic clinical signs in the guinea pig, resembling those occurring in cattle and sheep with diplodiosis, was isolated previously from a Stenocarpella maydis culture. Knowledge of the chemical properties of the toxin, which was characterised as a substituted ß-cyclopropylamino acid, enabled amendments in the present study to the initial steps of the isolation procedure. Extraction with water and fractionation by cation exchange chromatography improved the efficiency of isolation, potentially allowing the preparation of larger amounts of the toxin.
- Publication
Onderstepoort Journal of Veterinary Research, 2014, Vol 81, Issue 1, p1
- ISSN
0030-2465
- Publication type
Article
- DOI
10.4102/ojvr.v81i1.765