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- Title
Immunological Tolerance.
- Authors
Brian Medawar, Peter
- Abstract
The article reports that "immunological tolerance" may be described as a state of indifference or non-reactivity towards a substance that would normally be expected to excite an immunological response. The term first came to be used in the context of tissue transplantation immunity, of the form of immunity that usually prohibits the grafting of tissues between individuals of different genetic make-up; and it was used to refer only to a non-reactivity caused by exposing animals to antigenic stimuli before they were old enough to undertake an immunological response. For example, if living cells from a mouse of strain CBA are injected into an adult mouse of strain A, the CBA cells will be destroyed by an immuological process, and the A-line mouse that received them will destroy any later graft of the same origin with the speed to be expected of an animal immunologically forearmed.
- Subjects
TRANSPLANTATION immunology; IMMUNITY; IMMUNE response; IMMUNOLOGY; TISSUES; SEROLOGY
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 4, p338
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01779.x