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- Title
Age-Dependence of the IgA Anti-α(1→3) Dextran B1355 Response in Vitro.
- Authors
Rivier, D. A.; Trefts, P. E.; Kagnoff, M. F.
- Abstract
The magnitude of the Balb/c mouse IgA anti-α(1→3) dextran B1355 (anti-dex) response in vivo was recently found to be markedly T-cell-dependent and age-dependent. This report demonstrates that the in vitro IgA anti-dex response by mesenteric lymph nodes (MLN) is highly age-dependent and that there is an age-dependent increase of the background IgA anti-dex plaque-forming cell (PFC) response occurring in the absence of added antigen which correlates significantly with the magnitude of the antigen-stimulated response. In aging mice both background and antigen-stimulated IgA anti-des responses appeared to be significantly higher in MLN than in spleen cultures. Moreover, it is shown that there is a striking increase with age of natural antibody in the scrum of normal Balb/c to α(1→3) glucan determinants, particularly IgA and lesser amounts of IgM and IgG3.
- Subjects
IMMUNOGLOBULIN A; IMMUNOGLOBULINS; T cells; LYMPHOCYTES; LYMPH nodes; LYMPHATICS; SPLEEN; HEMATOPOIETIC system
- Publication
Scandinavian Journal of Immunology, 1983, Vol 17, Issue 2, p115
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1983.tb00773.x